Type 1 diabetes mellitus (T1D) is usually diagnosed when >80% of the pancreatic beta-cells are destroyed by the immune system. The autoimmune destruction of these cells is slow, providing a potentially long lag of time to identify individuals at risk, and maybe prevent T1D development. We can predict T1D development through the determination of some islet autoantibodies. However, these antibodies appear fairly late in the course of T1D, not being ideal biomarkers of the initial destruction of beta-cells. Therefore, new biomarkers are needed to improve the identification of at risk-individuals. MicroRNAs (miRNAs) are a class of small noncoding RNA molecules that negatively regulate gene expression by inducing target mRNA cleavage or by inhibiting protein translation. Changes in their expression were described in several pathological conditions, including autoimmune diseases. Circulating miRNAs are attractive biomarker candidates as they can be easily collected, are stable under different storage conditions and can be measured using specific assays.
Irresistibly action-packed and full of lethal surprises, this stunning new fantasy series from Victoria Aveyard, #1 New York Times bestselling author of the Red Queen series, begins where hope is lost and asks: When the heroes have fallen, who will take up the sword? A strange darkness grows in Allward. Even Corayne an-Amarat can feel it, tucked away in her small town at the edge of the sea. She soon discovers the truth: She is the last of an ancient lineage--and the last hope to save the world from destruction. But she won't be alone. Even as darkness falls, she is joined by a band of unlikely companions: A squire, forced to choose between home and honor. An immortal, avenging a broken promise. An assassin, exiled and bloodthirsty. An ancient sorceress, whose riddles hide an eerie foresight. A forger with a secret past. A bounty hunter with a score to settle. Together they stand against a vicious opponent, invincible and determined to burn all kingdoms to ash, and an army unlike anything the realm has ever witnessed.
"Santa brought us a good one, didn't he?" Bobby Watkins said as he and his wife took a walk amid the destruction in rural Benton County, Mississippi, where four people were confirmed dead. "I may have lost some stuff, but I got my life."
"He and I just huddled together and saw trees fly past us, and a shipping container flip over," Ables said. "And as the debris started hitting us, he just covered me, and within a minute it was all over and there was destruction all around us and we were fine." 2b1af7f3a8