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The association between migraine and menstrual cycle has been well established, the majority of previous studies reporting both an increased frequency of migraine during the premenstrual phase of the cycle and a decreased frequency of migraine during the post-menstrual phase. Headache in migraineurs may be aggravated by hormonal contraceptives; in particular, the oral contraceptives have been reported to worsen migraine attacks during the premenstrual phase. This was also observed when migraine was treated with estrogen or estrogen-progestin combination therapy, suggesting that the gonadal steroids influence the functional aspects of the brain which control pain processing. However, a protective effect of hormone therapy in migraine has also been reported. The exact mechanism by which hormonal contraceptives influence the migraine process is still not clear, but evidence sugges